Anti Cancer Injectables

• Application
• Other, Subcutaneous injection

• Dosage Form
• Solution for Injection

• Enzymatic Activity
• Not applicable; works via immunologic pathway

• Enzyme Types
• Other, Monoclonal Antibody Not an enzyme

• Feature
• Other, Ready-to-use prefilled syringe, convenient dosing, preservative-free

• Fermentation Smell
• Other, Odorless

• Indication
• Treatment of osteoporosis, bone loss, and prevention of skeletal-related events in patients with bone metastases

• Ingredients
• Other , Denosumab, excipients, sterile water

• Ph Level
• Neutral (around pH 6.0) - as per formulation standard

• Physical Color/Texture
• Other , Clear to slightly opalescent, colorless liquid

• Salt Composition
• Denosumab 60 mg/ml

• Shelf Life
• 24 months from date of manufacture

• Storage Instructions
• Store between 2C and 8C. Do not freeze. Keep in original package.

• Temperature Needed For Fermentation
• Not required (biotechnologically synthesized monoclonal antibody)

• Application
• Other, For intravenous administration after reconstitution

• Dosage Form
• Lyophilized Powder for Injection

• Enzymatic Activity
• Not applicable (monoclonal antibody)

• Enzyme Types
• Other, Monoclonal antibody (not an enzyme)

• Feature
• Other, High purity, specifically targets HER2 receptor, for targeted cancer therapy

• Fermentation Smell
• Other, Odorless

• Indication
• HER2-positive breast cancer, HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma

• Ingredients
• Other , Active: Trastuzumab; Excipients: L-histidine, L-histidine hydrochloride, trehalose dihydrate, polysorbate 20

• Ph Level
• Approximately 6.0

• Physical Color/Texture
• Other , White to pale yellow lyophilized powder

• Salt Composition
• Trastuzumab 440 mg

• Shelf Life
• 36 months from date of manufacture if unopened and stored properly

• Storage Instructions
• Store at 2C to 8C (36F to 46F), do not freeze

• Temperature Needed For Fermentation
• Not applicable (biotechnological production)

• Application
• Other, Medical treatment, typically administered subcutaneously or intravenously

• Dosage Form
• Injection

• Enzymatic Activity
• Stimulates erythropoiesis by acting on erythroid progenitor cells

• Enzyme Types
• Other, Erythropoiesis-stimulating agent

• Feature
• Other, Long-acting erythropoietin stimulating agent, single-use prefilled syringe

• Fermentation Smell
• Other, Odorless

• Indication
• Treatment of anemia associated with chronic renal failure and chemotherapy

• Ingredients
• Other , Darbepoetin Alfa with excipients (such as polysorbate, sodium chloride, sodium phosphate, etc.)

• Ph Level
• Approximately neutral (pH 6.0 - 7.5)

• Physical Color/Texture
• Other , Clear, colorless solution

• Salt Composition
• Darbepoetin Alfa 25 mcg

• Shelf Life
• 24 months from manufacture date

• Storage Instructions
• Store in refrigerator at 2C - 8C. Do not freeze.

• Temperature Needed For Fermentation
• 37C (typical for recombinant protein expression)

• Application
• Other, Increase production of red blood cells

• Dosage Form
• Injection

• Enzymatic Activity
• Stimulates erythropoiesis

• Enzyme Types
• Other, Erythropoiesis-stimulating agent (ESA)

• Feature
• Other, Ready-to-use pre-filled syringe; sterile and pyrogen-free

• Fermentation Smell
• Other, Odorless

• Indication
• Treatment of anemia associated with chronic renal failure and chemotherapy

• Ingredients
• Other , Darbepoetin Alfa, Excipient q.s.

• Ph Level
• 6.0 7.0 (approximate, isotonic buffer)

• Physical Color/Texture
• Other , Clear, colorless solution

• Salt Composition
• Darbepoetin Alfa 40 mcg

• Shelf Life
• 24 months from the date of manufacture

• Storage Instructions
• Store in a refrigerator (2C 8C). Do not freeze.

• Temperature Needed For Fermentation
• Not applicable (biotechnological synthesis)

• Application
• Other, Anti-cancer therapy

• Dosage Form
• Injection

• Enzymatic Activity
• Inhibits 26S proteasome

• Enzyme Types
• Other, Proteasome Inhibitor

• Feature
• Other, Lyophilized powder for reconstitution

• Fermentation Smell
• Other, Odorless

• Indication
• Multiple Myeloma, Mantle Cell Lymphoma

• Ingredients
• Other , Bortezomib (as base), Mannitol, Nitrogen

• Ph Level
• Neutral

• Physical Color/Texture
• Other , White to off-white lyophilized powder

• Salt Composition
• Bortezomib

• Shelf Life
• 24 months

• Storage Instructions
• Store below 25C, protect from light

• Application
• Other, Antineoplastic therapy

• Dosage Form
• Tablet

• Enzymatic Activity
• Inhibits poly(ADP-ribose) polymerase enzymes

• Enzyme Types
• Other, PARP Inhibitor

• Feature
• Other, Oral, high bioavailability

• Fermentation Smell
• Other, Odorless

• Indication
• Used in treatment of ovarian and breast cancer

• Ingredients
• Other , Olaparib, excipients

• Physical Color/Texture
• Other , Green film-coated tablet

• Salt Composition
• Olaparib 100 mg

• Shelf Life
• 24 months

• Storage Instructions
• Store below 30C, protect from light

• Application
• Other, Hospital, Oncology, Clinical

• Dosage Form
• Lyophilized Powder for Injection

• Enzyme Types
• Other, Not Applicable (Cytotoxic Antimetabolite Agent)

• Feature
• Other, Ready for reconstitution, sterile, pyrogen-free

• Fermentation Smell
• Other, Odorless

• Indication
• Treatment of Myelodysplastic Syndromes (MDS), including refractory anemia, chronic myelomonocytic leukemia, and acute myeloid leukemia (AML)

• Ingredients
• Other , Azacitidine, excipients

• Ph Level
• Neutral (6.57.5 when reconstituted)

• Physical Color/Texture
• Other , White to off-white lyophilized powder

• Salt Composition
• Azacitidine 100 mg

• Shelf Life
• 24 Months

• Storage Instructions
• Store below 25C, protect from light, do not freeze

• Application
• Other, Hospital, Clinical Use, Anti-coagulation therapy

• Dosage Form
• Injection

• Enzyme Types
• Other, Not applicable (anticoagulant/low molecular weight heparin)

• Feature
• Other, Prefilled syringe, ready-to-use, sterile

• Fermentation Smell
• Other, Odorless

• Indication
• Prevention and treatment of deep vein thrombosis, pulmonary embolism, and other thromboembolic disorders

• Ingredients
• Other , Enoxaparin Sodium, Water for Injection

• Ph Level
• 6.0 7.5

• Physical Color/Texture
• Other , Clear, colorless to pale yellow solution

• Salt Composition
• Enoxaparin Sodium 60 mg

• Shelf Life
• 24 months

• Storage Instructions
• Store below 25C, protect from light

• Application
• Other, Oral administration for prostate cancer therapy

• Dosage Form
• Tablet

• Enzyme Types
• Other, Non-enzymatic, small molecule anti-androgen

• Feature
• Other, Selective androgen receptor inhibitor; convenient oral dosage

• Fermentation Smell
• Other, Odorless

• Indication
• Treatment of non-metastatic castration-resistant prostate cancer (nmCRPC)

• Ingredients
• Other , Apalutamide with pharmaceutical excipients

• Physical Color/Texture
• Other , Light yellow, round, film-coated tablet

• Salt Composition
• Apalutamide 60 mg

• Shelf Life
• 24 months

• Storage Instructions
• Store below 30C, keep in a dry place away from sunlight

• Application
• Other, Antineoplastic (Chemotherapy)

• Dosage Form
• Lyophilized Powder for Injection

• Feature
• Other, Ready for reconstitution

• Fermentation Smell
• Other, Odorless

• Indication
• Malignant pleural mesothelioma, Non-small cell lung cancer

• Ingredients
• Other , Pemetrexed Disodium Hemipentahydrate

• Ph Level
• 6.6-7.0 (when reconstituted)

• Physical Color/Texture
• Other , White to off-white lyophilized powder

• Salt Composition
• Pemetrexed Disodium 100 mg/vial

• Shelf Life
• 24 months

• Storage Instructions
• Store below 25C, protect from light

• Application
• Other, Intravenous infusion for cancer treatment

• Dosage Form
• Injection

• Enzyme Types
• Other, Not applicable (chemotherapeutic agent)

• Feature
• Other, Sterile, single use vial, non-pyrogenic

• Indication
• Ovarian cancer, breast cancer, non-small cell lung cancer and other solid tumors

• Ingredients
• Other , Paclitaxel, Cremophor EL, anhydrous ethanol, citric acid, sodium citrate

• Ph Level
• 2.73.3

• Physical Color/Texture
• Other , Clear, colorless to pale yellow viscous solution

• Salt Composition
• Paclitaxel IP 260 mg/43.4 ml (6 mg/ml)

• Shelf Life
• 24 months

• Storage Instructions
• Store below 25C, protect from light

• Application
• Other, Intravenous administration by healthcare professional

• Dosage Form
• Injection

• Enzyme Types
• Other, Not applicable (Chemotherapy agent)

• Feature
• Other, Sterile, single-use vial

• Indication
• Breast cancer, non-small cell lung cancer, prostate cancer, stomach cancer, head and neck cancer

• Ingredients
• Other , Docetaxel, polysorbate 80, dehydrated alcohol

• Ph Level
• 2.7-3.3

• Physical Color/Texture
• Other , Clear, colorless to pale yellow, viscous solution

• Salt Composition
• Docetaxel (20mg) per vial

• Shelf Life
• 24 months

• Storage Instructions
• Store below 25C, protect from light

• Application
• Other, Intravenous use

• Dosage Form
• Injection

• Feature
• Other, Single-use vial, cytotoxic agent

• Fermentation Smell
• Other, Odorless

• Indication
• Treatment of non-small cell lung cancer and advanced breast cancer

• Ingredients
• Other , Vinorelbine tartrate and excipients

• Ph Level
• Approximately 3.5

• Physical Color/Texture
• Other , Clear, colorless to pale yellow liquid

• Salt Composition
• Vinorelbine 50 mg

• Shelf Life
• 24 months

• Storage Instructions
• Store at 2C to 8C. Do not freeze. Keep away from light.

• Application
• Other, Intravenous use only, chemotherapy regimen

• Dosage Form
• Injection

• Feature
• Other, Pegylated liposomal formulation for prolonged circulation and reduced cardiotoxicity

• Fermentation Smell
• Other, Odorless

• Indication
• Cancer (various types including breast cancer, ovarian cancer, multiple myeloma, Kaposis sarcoma)

• Ingredients
• Other , Doxorubicin Hydrochloride in a Liposomal formulation

• Ph Level
• Neutral (approx. pH 7.0)

• Physical Color/Texture
• Other , Translucent red solution

• Salt Composition
• Doxorubicin Hydrochloride Liposome

• Shelf Life
• 24 months from manufacturing date

• Storage Instructions
• Store at 2C to 8C. Do not freeze. Protect from light.

• Application
• Other, Intravenous Use

• Dosage Form
• Injection

• Feature
• Other, Sterile, Single Dose Vial, Antineoplastic Agent

• Fermentation Smell
• Other, Odorless

• Indication
• Prostate Cancer (Metastatic Castration-Resistant Prostate Cancer)

• Ingredients
• Other , Cabazitaxel, Polysorbate 80, Citric Acid, Ethanol, Water for Injection

• Ph Level
• Not indicated

• Physical Color/Texture
• Other , Clear, Colorless to Slightly Yellow Solution

• Salt Composition
• Cabazitaxel 60 mg

• Shelf Life
• 24 months

• Storage Instructions
• Store below 25C, Protect from Light, Do Not Freeze

• Application
• Other, Intravenous use

• Dosage Form
• Injection

• Feature
• Other, Single dose vial, ready-to-use solution

• Fermentation Smell
• Other, Odorless

• Indication
• Osteoporosis, Hypercalcemia of malignancy, Pagets disease

• Ingredients
• Other , Zoledronic Acid, Excipient, Water for Injection

• Ph Level
• Approximately 6.0-7.0

• Physical Color/Texture
• Other , Clear, colorless solution

• Salt Composition
• Zoledronic Acid 5mg/100ml

• Shelf Life
• 24 months

• Storage Instructions
• Store below 30C, protect from light

• Application
• Other, Oncology

• Dosage Form
• Film-coated Tablet

• Feature
• Other, Prescription medicine for targeted cancer therapy

• Fermentation Smell
• Other, Odorless

• Indication
• Treatment of chronic myeloid leukemia (CML)

• Ingredients
• Other , Bosutinib monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, polyethylene glycol

• Physical Color/Texture
• Other , Light yellow, round, film-coated tablet

• Salt Composition
• Bosutinib 100 mg

• Shelf Life
• 24 months

• Storage Instructions
• Store below 30C, protect from moisture and light

• Application
• Other, Hospital, Clinical, Prescribed under medical supervision

• Dosage Form
• Injection (Pre-filled Syringe)

• Feature
• Other, Ready to use, single-use pre-filled syringe

• Fermentation Smell
• Other, Odorless

• Indication
• Prevention and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE)

• Ingredients
• Other , Fondaparinux Sodium, Water for Injection, Sodium chloride (as required)

• Physical Color/Texture
• Other , Clear, colorless solution

• Salt Composition
• Fondaparinux Sodium 2.5 mg

• Shelf Life
• 24 months from the date of manufacture

• Storage Instructions
• Store below 25C, do not freeze, keep in original packaging to protect from light

• Application
• Other, Oral use for increasing platelet counts

• Dosage Form
• Tablet

• Feature
• Other, Prescription medication, high bioavailability, once-daily dosing

• Indication
• Treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP), hepatitis C-associated thrombocytopenia, and severe aplastic anemia

• Ingredients
• Other , Eltrombopag olamine, excipients

• Physical Color/Texture
• Other , Film-coated tablet; color may vary depending on manufacturer (commonly brown, round)

• Salt Composition
• Eltrombopag 50 mg

• Shelf Life
• 24 months from date of manufacture

• Storage Instructions
• Store below 30C, protect from light and moisture